The Structural Evolution of Outer Membrane Beta Barrels

Date: 
Monday, February 4, 2019 - 4:00pm

Outer membrane proteins (OMPs) are the proteins in the surface of Gram-negative bacteria. These proteins have diverse functions but a single topology: the β-barrel. I will discuss the evolutionary pathways and origins of this topology. The mechanisms of diversification have implications for antibiotic resistance, repeat protein biogenesis, and the nucleation of outermembrane protein folding.   

Speaker: 
Prof. Joanna Slusky - U. Kansas
Host: 
Gavin King