Keith Cassidy

Keith Cassidy Image
Assistant Professor
218 Physics

PhD, University of Illinois at Urbana-Champaign

Research Summary

Molecular dynamics simulation, protein structure modeling, computational biophysics

Research Description

The Cassidy Lab uses a wide range of computational techniques, including integrative and multi-scale molecular simulations, to study the structure and function of diverse biomolecular systems. We’re especially interested in understanding signal transduction mechanisms within the chemosensory arrays mediating bacterial chemotaxis. These remarkable complexes display exquisite sensing capabilities that begin with subtle allosteric changes in individual proteins and emerge from the cooperative interaction of dozens of components, presenting tantalizing challenges to the modeler. We work closely with structural biologists, geneticists, and biochemists to connect our in silico observations to cellular behavior, providing unique, high-resolution insight into critical cellular processes.